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Latest articles        [more info]
Study protocol    
Protocol of a randomized controlled trial of the effectiveness of physician education and activation versus two rehabilitation programs for the treatment of Whiplash-associated Disorders. The University Health Network Whiplash Intervention Trial
Pierre Cote, J DAVID Cassidy, Simon Carette, Eleanor Boyle, Heather M Shearer, Maja Stupar, Carlo Ammendolia, Gabrielle van der Velde, Jill A Hayden, Xiaoqing Yang, Maurits van Tulder, John W Frank
Trials 2008, 9:75 (24 December 2008)
[Abstract] [Provisional PDF] [PubMed] [Related articles]

Study protocol    
Prospective controlled randomized trial on prevention of postoperative abdominal adhesions by Icodextrin 4% solution after laparotomic operation for small bowel obstruction caused by adherences (POPA study: Prevention of Postoperative Adhesions)
Fausto Catena, Luca Ansaloni, Augusto Lauro, Girogio Ercolani, Luigi D'Alessandro, Antonio Pinna
Trials 2008, 9:74 (18 December 2008)
[Abstract] [Provisional PDF] [PubMed] [Related articles]

Study protocol    
Community-based trial of screening for Chlamydia trachomatis to prevent pelvic inflammatory disease: the POPI (prevention of pelvic infection) trial.
Pippa Oakeshott, Sally Kerry, Helen Atherton, Adamma Aghaizu, Sima Hay, David Taylor-Robinson, Ian Simms, Phillip Hay
Trials 2008, 9:73 (10 December 2008)
[Abstract] [Provisional PDF] [PubMed] [Related articles] [1 comment]

Study protocol    
Ultrasound enhanced prehospital thrombolysis using microbubbles infusion in patients with acute ST elevation myocardial infarction: rationale and design of the Sonolysis study
Jeroen Slikkerveer, Pieter A. Dijkmans, Gertjan T. Sieswerda, Pieter A.F.M. Doevendans, Arie P.J. van Dijk, Freek W.A. Verheugt, Thomas R. Porter, Otto Kamp
Trials 2008, 9:72 (10 December 2008)
[Abstract] [Provisional PDF] [PubMed] [Related articles]

Research    
A randomized, double blind, crossover, placebo-controlled clinical trial to assess the effects of a mouthwash containing chlorine dioxide on oral malodor
Kayoko Shinada, Masayuki Ueno, Chisato Konishi, Sachiko Takehara, Sayaka Yokoyama, Yoko Kawaguchi
Trials 2008, 9:71 (9 December 2008)
[Abstract] [Provisional PDF] [PubMed] [Related articles]

Study protocol    
Study Protocol: effects of acupuncture on hot flushes in perimenopausal and postmenopausal women - a multicenter randomized clinical trial
Kun-Hyung Kim, Kyung-Won Kang, Hee-Jung Jung, Ji-Eun Park, So-Young Jung, Jun-Yong Choi, Sun-Mi Choi
Trials 2008, 9:70 (3 December 2008)
[Abstract] [Provisional PDF] [PubMed] [Related articles]

Methodology    
Reporting of noninferiority and equivalence randomized trials for major prostaglandins: a systematic survey of the ophthalmology literature
Oghenowede Eyawo, Chia-Wen Lee, Beth Rachlis, Edward J Mills
Trials 2008, 9:69 (3 December 2008)
[Abstract] [Provisional PDF] [PubMed] [Related articles]

Study protocol    
Safety of magnetic resonance imaging of patients with a new Medtronic EnRhythm MRI SureScan pacing system: clinical study design
Richard Sutton, Emanuel Kanal, Bruce L Wilkoff, David Bello, Roger Luechinger, Inge Jenniskens, Michael Hull, Torsten Sommer
Trials 2008, 9:68 (2 December 2008)
[Abstract] [Provisional PDF] [PubMed] [Related articles]

Study protocol    
Early intervention in panic: randomized controlled trial and cost-effectiveness analysis
Peter Meulenbeek, Godelief Willemse, Filip Smit, Anton van Balkom, Philip Spinhoven, Pim Cuijpers
Trials 2008, 9:67 (27 November 2008)
[Abstract] [Provisional PDF] [PubMed] [Related articles]

Research    
Reporting of clinical trials: a review of research funders' guidelines
Kerry Dwan, Carrol Gamble, Paula R Williamson, Douglas G Altman
Trials 2008, 9:66 (25 November 2008)
[Abstract] [Provisional PDF] [PubMed] [Related articles]

Study protocol    
VAST: Vertebral Artery Stenting Trial. Protocol for a randomised safety and feasibility trial
A Compter, HB van der Worp, WJ Schonewille, JA Vos, A Algra, TH Lo, WPThM Mali, FL Moll, LJ Kappelle
Trials 2008, 9:65 (24 November 2008)
[Abstract] [Full Text] [PDF] [PubMed] [Related articles]

Letter    
Economic evaluation alongside pragmatic randomised trials: developing a standard operating procedure for clinical trials units
Rhiannon T Edwards, Barry Hounsome, Pat Linck, Ian T Russell
Trials 2008, 9:64 (17 November 2008)
[Abstract] [Provisional PDF] [PubMed] [Related articles]

Study protocol    
ZAMSTAR, The Zambia South Africa TB and HIV Reduction study: Design of a 2 × 2 factorial community randomized trial
Helen M Ayles, Charalambos Sismanidis, Nulda Beyers, Richard J Hayes, Peter Godfrey-Faussett
Trials 2008, 9:63 (7 November 2008)
[Abstract] [Full Text] [PDF] [PubMed] [Related articles]

Study protocol    
Community-based randomised controlled trial evaluating falls and osteoporosis risk management strategies
PM Ciaschini, SE Straus, LR Dolovich, RA Goeree, KM Leung, CR Woods, GM Zimmerman, SR Majumdar, S Spadafora, LA Fera, HN Lee
Trials 2008, 9:62 (4 November 2008)
[Abstract] [Full Text] [PDF] [PubMed] [Related articles]

Study protocol    
Clinical and cost-effectiveness of internal limiting membrane peeling for patients with idiopathic full thickness macular hole. Protocol for a Randomised Controlled Trial: FILMS (Full-thickness macular hole and Internal Limiting Membrane peeling Study)
Noemi Lois, Jennifer Burr, John Norrie, Luke Vale, Jonathan Cook, Alison McDonald, the Full-thickness macular hole and Internal Limiting Membrane peeling Study (FILMS) Group
Trials 2008, 9:61 (3 November 2008)
[Abstract] [Full Text] [PDF] [PubMed] [Related articles]

Study protocol    
Protocol of an expertise based randomized trial comparing surgical Venae Sectio versus radiological Puncture of Vena Subclavia for insertion of Totally Implantable Access Port in oncological patients
Philip Knebel, Lars Fischer, Eva Cremonese, Ruben Lopez-Benitez, Ulrike Stampfl, Boris Radeleff, Hans-Ulrich Kauczor, Markus W Büchler, Christoph M Seiler
Trials 2008, 9:60 (24 October 2008)
[Abstract] [Full Text] [PDF] [PubMed] [Related articles]

Study protocol    
Study design and methods of the BoTULS trial: a randomised controlled trial to evaluate the clinical effect and cost effectiveness of treating upper limb spasticity due to stroke with botulinum toxin type A
Helen Rodgers, Lisa Shaw, Christopher Price, Frederike van Wijck, Michael Barnes, Laura Graham, Gary Ford, Phil Shackley, Nick Steen, BoTULS investigators
Trials 2008, 9:59 (23 October 2008)
[Abstract] [Full Text] [PDF] [PubMed] [Related articles]

Study protocol    
Perioperative oxygen fraction effect on surgical site infection and pulmonary complications after abdominal surgery: a randomized clinical trial. Rationale and design of the PROXI-Trial
Christian S Meyhoff, Jørn Wetterslev, Lars N Jorgensen, Steen W Henneberg, Inger Simonsen, Therese Pulawska, Line R Walker, Nina Skovgaard, Kim Heltø, Peter Gocht-Jensen, Palle S Carlsson, Henrik Rask, Sharaf Karim, Charlotte G Carlsen, Frank S Jensen, Lars S Rasmussen, the PROXI Trial Group
Trials 2008, 9:58 (22 October 2008)
[Abstract] [Full Text] [PDF] [PubMed] [Related articles]

Study protocol    
Randomized controlled trial to treat migraine with acupuncture: design and protocol
Ying Li, Fanrong Liang, Shuguang Yu, Xuguang Liu, Yong Tang, Xuguang Yang, Xiaoping Tian, Jie Yan, Guojie Sun, Xiaorong Chang, Hui Zheng, Hongxing Zhang, Tingting Ma
Trials 2008, 9:57 (20 October 2008)
[Abstract] [Full Text] [PDF] [PubMed] [Related articles]

Study protocol    
A randomised, double-masked phase III/IV study of the efficacy and safety of Avastin® (Bevacizumab) intravitreal injections compared to standard therapy in subjects with choroidal neovascularisation secondary to age-related macular degeneration: clinical trial design
Praveen J Patel, Catey Bunce, Adnan Tufail, the ABC Trial Investigators
Trials 2008, 9:56 (14 October 2008)
[Abstract] [Full Text] [PDF] [PubMed] [Related articles]

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