 CommentaryDebate: A subversive view of subsets - a dissident clinician's opinionDesmond G Julian  Netherhall Gardens, London NW3 5RN, UK  author email corresponding author email
Current Controlled Trials in Cardiovascular Medicine 2000,
1:28-30doi:10.1186/cvm-1-1-028 Abstract
Clinical trialists and statisticians are very wary of subgroup analysis, for good reasons. Clinicians have to deal with situations in which subgroups of patients differ widely from one another in their prognosis and response to treatment. Few trials are large enough to demonstrate convincingly these differences in outcome, but often provide suggestive evidence. Should we ignore this and treat all patients as the same, or should we allow dubious statistical evidence to buttress biological plausibility in making clinical decisions? | 
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